H2 inhibition of lung cancer through the influence of SMC3
- Journal：Biomedicine & Pharmacotherapy
- Disease Model：Lung cancer cell line
- Corresponding Author：Dongchang Wang, Lifei Wang, Gang Chen, et al.
- Corresponding Unit：No
- Experimental Subject：mice
- Way of Hydrogen Administration：67% H2 / 33% O2 Mixture
- Dosage：67% H2 / 33% O2 Mixture
- Duration：2h/d for 1 month
H2 can inhibit the growth, migration and invasion of cancer cells, and catalyze the apoptosis of cells. H2 induced A549 and H1975 remain in the g2/m phase of the cell cycle; In addition, H2 lowered NIBPL, SMC3, SMC5 and SMC6 expression ... All data showed that H2 can inhibit the progression of lung cancer and regulate SMC3, which provides a new method for the treatment of lung cancer.
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